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Background
The human HTR3A gene encodes the pore-forming subunit of 5-HT3A, a ligand-gated cation channel activated by 5-hydroxytryptamine (serotonin). 5-HT3A channels expressed in the CNS and GI tract, are therapeutic targets in nausea and irritable bowel syndrome.
| General Info | |
| Product Description | Human 5-HT3A Serotonin Receptor-expressing, stable replicating cell line. |
|---|---|
| Target Type | Ion Channel |
| Product Type | Replicating Cell Line |
| Family | Ligand-Gated |
| Receptor | Serotonin |
| Sub-Type | 5-HT3A |
| Class | Ligand-gated cation channel |
| Therapeutic Area | metabolic & gastrointestinal |
| Related Services | Large-scale Cryopreservation |
| Gene Name | HTR3A |
| Validated Assay/Platform | FLIPR®, IonWorks Quattro™, manual patch clamp, PatchXpress® |
| References | Thompson AJ and Lummis SCR. 2006. Curr Pharm Des. 12:3615-3630. 5-HT3 Receptors. |
| Host cell | HEK293 |
| Mycoplasma Status | Negative (MycoAlert Kit) |
| Storage & Packaging | |
| Packaging | Cryopreserved cells, 1-2x106 cells |
| Storage Recommendation | liquid nitrogen |
| Quantity | 1-2 million cells |
| Product Documentation | |
| Specification Sheet |  Download PDF Document |
