Automated Screening Assays:
FLIPRTetra®
Assay Features:
- 10,000 points per day
- Uses adherent or non-adherent cell lines
- Primary cultures of native cells available
Applications:
- Primary screening of membrane potential, intracellular calcium, potassium (thallium) flux
- Re-screening
Assays
| Intracellular Calcium–signaling by: |
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| Membrane Potential: |
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| Customized molecular biology services for GPCRs and Tandem-Pore channels |
| Family | Channel |
|---|---|
| Ligand-gated | 5-HT3A |
| Calcium, voltage-gated | Cav3.2 (T-type) |
| GABA-A (α1/β2/γ2) | |
| GABA-A (α2/β2/γ2) | |
| GABA-A (α5/β2/γ2) | |
| Calcium release activated current | ICRAC |
| Potassium, inward rectifier | Kir6.2/SUR2A |
| Potassium, voltage-gated | Kv7.2/Kv7.3 (KCNQ2/KCNQ3) |
| Kv7.3/Kv7.5 (KCNQ3/KCNQ5) | |
| Kv7.4 (KCNQ4) | |
| Sodium, voltage-gated | Nav1.5 |
| Sodium/calcium exchanger | NCX1 |
| Ligand-gated | Nicotinic receptor (nAChR) α3/β4 |
| Nicotinic receptor (nAChR) α7 | |
| NMDA receptor (NR1/NR2A) | |
| NMDA receptor (NR1/NR2B) | |
| Purinergic receptors | P2X1 |
| P2X2 | |
| P2X2/P2X3 | |
| P2X3 | |
| P2X4 | |
| Potassium, calcium-activated | SK2 (KCa2.2) |
| SK3 (KCa2.3) | |
| TRP (transient receptor potential) | TRPA1 |
| TRPC6 | |
| TRPM4 | |
| TRPM8 | |
| TRPV1 | |
| TRPV4 |
Download: Ion Channel targets and current platform validation list.
For a quote or additional information, please email inquiries@chantest.com or call 216-332-1665.