Automated Screening Platforms
The development of automated patch clamp and fluorescent assay platforms for ion channel research has made it cost-effective to screen and profile promising leads and to assess potential liabilities earlier in the drug discovery and development process. The ion channel experts at ChanTest can help in guiding studies to the most appropriate platform for assessing your profiling needs.
| PatchXpress® or QPatch-HT | IonWorks Quattro® | FLIPRTETRA® | |
|---|---|---|---|
| Service | FASTPatch® | ScreenPatch® | FLIPRTETRA® |
| Throughput | Low | Medium | High |
| Datapoints per day | 10-100’s | 100-1000’s | 10,000+ |
| Seal Quality | GΩ seal | MΩ seal | n/a |
| Compound requirements | 1-2 mg | 1 mg or less* | 1 mg or less* |
| Washout | Yes | No | Yes |
| Assay Temperature | RT | RT | RT or 37oC |
| TurboSol™ Solubility Testing | Yes | Yes | Yes |
| * when material is sent as a stock solution | |||
A list of validated targets for individual platforms can be accessed through the following links:
- PatchXpress® (FASTPatch®)
- QPatch HT (FASTPatch®)
- IonWorks Quattro™ (ScreenPatch®)
- FLIPRTETRA®
- Manual Patch Clamp
Download: Ion Channel targets and current platform validation list.
For a quote or additional information, please email inquiries@chantest.com or call 216-332-1665.
