Ion Channel Screens & Concentration Response Assays

Functional, validated Ion Channel cell-based assays for screening and profiling

ChanTest’s Ion Channel portfolio includes over 90 targets. All assays are fully validated by ChanTest’s expert electrophysiologists, and have been designed to provide high quality screening and profiling data for both drug discovery and safety assessments.

To receive a quote or for additional information, please email inquiries@chantest.com or call 216-332-1665. Check back regularly for an updated listing of available targets.

TargetFamilyValidation*
5-HT3ALigand-GatedFLP, IWQ, MP, PX
a3/β4Ligand-GatedFLP
ASIC1aAcid-SensingPX
ASIC2aAcid-SensingPX
ASIC3Acid-SensingPX, QP
Cav1.2/β2/α2δ1Calcium, Voltage-GatedIWQ, MP, PX, QP
Cav2.1/β4/α2δ1Calcium, Voltage-GatedIWQ, MP, PX, QP
Cav2.2/β3/α2δ1Calcium, Voltage-GatedIWQ, MP, PX, QP
Cav3.2Calcium, Voltage-GatedIWQ, PX
CFTRChlorideIWQ, QP
ClC-1ChloridePX
ClC-2 ChloridePX, QP
ENaCSodium, EpithelialMP
GABA-A (α3/β2/γ2)Ligand-GatedFLP
GABAA (a2β2γ2)Ligand-GatedFLP
GABAA (a5β2γ2)Ligand-GatedFLP, QP
GABAA122)Ligand-GatedFLP
HCN1Hyperpolarization-gatedPX
HCN2Hyperpolarization-gatedIWQ, PX, QP
HCN4Hyperpolarization-gatedIWQ, QP
ICRACCalcium release activated currentFLP
KCa1.1Potassium, Calcium-ActivatedPX
KCa2.1Potassium, Calcium-ActivatedMP
KCa2.2Potassium, Calcium-ActivatedFLP, MP
KCa2.3Potassium, Calcium-ActivatedFLP
KCa3.1Potassium, Calcium-ActivatedPX, QP
Kir1.1Potassium, Inward RectifierMP
Kir2.1Potassium, Inward RectifierIWQ, QP
Kir3.1/Kir3.4Potassium, Inward RectifierPX
Kir6.2/SUR2APotassium, Inward RectifierPX, QP
Kv1.1Potassium, Voltage-GatedIWQ, PX, QP
Kv1.2Potassium, Voltage-GatedQP
Kv1.3Potassium, Voltage-GatedIWQ
Kv1.4Potassium, Voltage-GatedIWQ, QP
Kv1.5Potassium, Voltage-GatedIWQ, QP
Kv1.6Potassium, Voltage-GatedMP
Kv1.7Potassium, Voltage-GatedMP
Kv11.1Potassium, Voltage-GatedIWQ, QP
Kv3.4Potassium, Voltage-GatedIWQ, PX
Kv4.2/KChIP2.2Potassium, Voltage-GatedMP, PX, QP
Kv4.3Potassium, Voltage-GatedIWQ, PX, QP
Kv4.3/KChIP2.2Potassium, Voltage-GatedIWQ, MP, QP
Kv7.1Potassium, Voltage-GatedIWQ, MP, QP
Kv7.2/Kv7.3Potassium, Voltage-GatedFLP, PX, QP
Kv7.2/Kv7.4Potassium, Voltage-GatedPX
Kv7.3/Kv7.5Potassium, Voltage-GatedFLP, PX, QP
Kv7.4Potassium, Voltage-GatedFLP, PX, QP
nAChR α7Ligand-GatedFLP, QP
Nav1.1Sodium, Voltage-GatedIWQ, QP
Nav1.2Sodium, Voltage-GatedIWQ, QP
Nav1.3Sodium, Voltage-GatedIWQ, PX, QP
Nav1.4Sodium, Voltage-GatedIWQ, QP
Nav1.5Sodium, Voltage-GatedIWQ, PX, QP
Nav1.6Sodium, Voltage-GatedIWQ, PX, QP
Nav1.8/β3Sodium, Voltage-GatedFLP
NCX1 Na+/Ca2+ExchangerFLP
Nicotinic receptor (nAChR) α1Ligand-GatedMP
Nicotinic receptor (nAChR) α3Ligand-GatedFLP
NMDA (NR1/NR2A)Ligand-GatedFLP
NMDA (NR1/NR2B)Ligand-GatedFLP
P2X1Ligand-GatedFLP
P2X2Ligand-GatedFLP, QP
P2X2/P2X3Ligand-GatedFLP
P2X3Ligand-GatedFLP
P2X4Ligand-GatedFLP, PX, QP
TRPA1TRPFLP, MP
TRPC1TRPMP
TRPC6TRPFLP, MP
TRPM4TRPFLP
TRPM8TRPFLP, MP, PX, QP
TRPV1TRPFLP, MP
TRPV4TRPFLP
TRPV6TRPMP
* MP: manual patch clamp - PX: PatchXpress® - QP: QPatch HT
IWQ: IonWorks Quattro™ - FPR: FLIPRTETRA®

 

Download: Ion Channel targets and current platform validation list.

For a quote or additional information, please email inquiries@chantest.com or call 216-332-1665.