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General profiling assays:
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Channel Panels – by organ or therapeutic area
Cardiac Channel Panel
CNS Channel Panel
Pain Channel Panel
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Ion Channel Catalog – the broadest list of validated ion channels available |
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FASTPatch moderate-throughput screening – tabular results, ranked to identify the safety of drug candidates |
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Super FASTPatch high-throughput screening – tabular results, ranked to identify the safety of drug candidates |
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FLIPR highest-throughput screening – measures thallium membrane potential, calcium concentration for calcium-permeant channels and potassium (thallium) flux for voltage-gated and calcium-activated potassium channels |
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Ranking within profiles – multi-concentration/compound screens:
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One channel FASTPatch moderate-throughput screen – tabular results, ranked to identify the safety of drug candidates |
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One channel Super FASTPatch high-throughput screen – tabular results, ranked to identify the safety of drug candidates |
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Multi-channel FASTPatch moderate-throughput screen – tabular results, ranked to identify the safety of drug candidates
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Multi-channel Super FASTPatch high-throughput screen – tabular results, ranked to identify the safety of drug candidates |
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Ranking within profiles – additional screens:
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HERG-Lite screen – economically identifies hidden hERG trafficking inhibition
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FAST & Lite (FASTPatch® & HERGLite®) – Provides a comprehensive valuation of hERG inhibition – both direct block & defective trafficking
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hERG 450 – Identifies drug-drug interaction risk
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