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FDA Critical Path Tools/Biomarkers
Toxicity Screening & Selectivity Profiling of Cardiac Ion Channels System:
FASTPatch automated patch clamp system (PatchXpress 7000A, QPatch)
Benefits:
- Complements S7B integrated cardiac risk assessment
- Provides mechanistic interpretation
- Predicts proarrhythmia potential
- Fully validated by ChanTest’s expert electrophysiologists
| Available Assays |
| Channel Panel Profiling Screen |
- Screen channels on 1 concentration @ n=2, plus positive control per study
- Report includes a table of % inhibition by channel for each compound
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| Channel Panel IC50 Screen |
- Screen channels on 6 concentrations @ n=2, plus positive control
- Report includes a concentration-response curve and IC50 by channel for each compound
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Channels available NOW
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| Cav1.2, α2-δ, β2(L-type) |
| Cav3.2 (T-type ) |
| HCN2 |
| HCN4 |
| hERG** |
| Kir2.1** |
| Kir3.1/3.4 |
| Kir6.1SUR2A |
| Kv1.5** |
| Kv4.3** |
| KvLQT1/minK** |
| Nav1.5** |
| NCX1* |
Channels without asterisks are validated in manual patch & FASTPatch
* validated in manual patch only
**validated in manual patch, FASTPatch, & Super FASTPatch
 SAB-cardiac channel panel.pdf
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