|
|
ISOLATED HEART QT PROLONGATION ASSAYS
If your Drug has a Positive hERG Signal, Does it have a QT Risk?
The CT-QT Assay is more than a QT Measurement!
- Paced heart model – No QT correction required!
- Measures drug effects on isolated rabbit hearts:
CT-QT Screen: QT only; or
CT-QT: QT, plus contractility (LVP, dP/dtmax & dP/dtmin) & MAPD
GLP & non-GLP protocols available
- Positive & vehicle controls
- Performed at physiological temperature 37 + 1° C
| Standard Assay Parameters |
| Protocol |
GLP or Non-GLP
|
Screen
|
| Number of concentrations tested |
3
|
3
|
| Number of hearts per concentration |
4
|
3
|
Additional Options:
- Dose Solution Analysis – GLP & non-GLP; verify applied concentrations
- Coronary Blood Flow & QRS Data – quoted by study
- Additional copies of final report (one provided with study)
- Copies of solution worksheets and data collection forms
- Electronic copy of report (pdf) on CD-ROM
- Nonclinical Integrated Risk Assessment report – data from ChanTest dose-response & repolarization reports, plus sponsor’s effective therapeutic plasma concentration data, compiled into one report
 CRB-isolated heart QT prolongation.pdf
|
|
|
|